| Year | Enrollment |
| 1805 | 30 |
| 1806 | 57 |
| 1807 | 93 |
| 1808 | 107 |
| 1809 | 92 |
| 1810 | 105 |
| 1811 | 118 |
| 1812 | 171 |
| 1813 | 141 |
| 1814 | 149 |
| 1815 | 134 |
| 1816 | 108 |
| 1817 | 113 |
| 1818 | 107 |
| 1819 | 107 |
| 1820 | 110 |
| 1821 | 88 |
| 1822 | 76 |
| 1823 | 65 |
| 1824 | 108 |
| 1825 | 115 |
| 1826 | 114 |
| 1827 | 114 |
| 1828 | 87 |
| 1829 | 97 |
| 1830 | 115 |
| 1831 | 114 |
| 1832 | 108 |
| 1833 | 86 |
| 1834 | 52 |
| 1835 | 70 |
| 1836 | 114 |
| 1837 | 155 |
| 1838 | 153 |
| 1839 | 160 |
| 1840 | 168 |
| 1841 | 169 |
| 1842 | 150 |
| 1843 | 134 |
| 1844 | 134 |
| 1845 | 122 |
| 1846 | 137 |
| 1847 | 171 |
| 1848 | 221 |
| 1849 | 237 |
| 1850 | 195 |
| 1851 | 184 |
| 1852 | 199 |
| 1853 | 122 |
| 1854 | 190 |
| 1855 | 195 |
| 1856 | 180 |
| 1857 | 158 |
| 1858 | 201 |
| 1859 | 184 |
| 1860 | 170 |
| 1861 | 143 |
| 1862 | 72 |
| 1863 | closed |
| 1864 | closed |
| 1865 | closed |
| 1866 | 48 |
| 1867 | 108 |
| 1868 | 113 |
| 1869 | 65 |
| 1870 | 53 |
| 1871 | 88 |
| 1872 | 68 |
| 1873 | 62 |
| 1874 | radical |
| 1875 | radical |
| 1876 | radical |
| 1877 | radical |
| 1878 | closed |
| 1879 | closed |
| 1880 | closed |
| 1881 | 66 |
| 1882 | 72 |
| 1883 | 185 |
| 1884 | 202 |
| 1885 | 184 |
| 1886 | 213 |
| 1887 | 192 |
| 1888 | 170 |
| 1889 | 235 |
| 1890 | 226 |
| 1891 | 182 |
| 1892 | 98 |
| 1893 | 72 |
| 1894 | 68 |
| 1895 | 160 |
| 1896 | 184 |
| 1897 | 162 |
| 1898 | 189 |
| 1899 | 184 |
| 1900 | 212 |
| 1901 | 227 |
| 1902 | 215 |
| 1903 | 226 |
| 1904 | 214 |
| 1905 | 296 |
| 1906 | 301 |
| 1907 | 285 |
| 1908 | 278 |
| 1909 | 298 |
| 1910 | 339 |
| 1911 | 416 |
| 1912 | 443 |
| 1913 | 513 |
| 1914 | 551 |
| 1915 | 511 |
| 1916 | 578 |
| 1917 | 355 |
| 1918 | 201* |
| 1919 | 312 |
*Civilian enrollment only
See other historical enrollment data: 1920 - 1955 | 1956 - 1997
Sources:
Green, Edwin L., A History of the University of South Carolina 1916
Hollis, D.W. University of South Carolina, Vol. 1956
"Annual Report of the Registrar to the President of the University of South Carolina"
1971 University of South Carolina Self Study, Vol 1, p.408
Office of Institutional Planning and Research