| President | Andrew A. Sorensen |
| Executive Vice President for Academic Affairs and Provost | Jerome D. Odom |
| Vice President and Chief Financial Officer | Richard W. Kelly |
| Secretary of the Board of Trustees and University Secretary and Treasurer | Thomas L. Stepp |
| Vice President for Human Resources | Jane M. Jameson |
| Vice President for Medical Affairs | Larry R. Faulkner |
| Vice President for Student and Alumni Services | Dennis A. Pruitt |
| General Counsel | Walter H. Parham |
| Interim Vice President for Research | Harris Pastides |
| Vice President for Information Technology and Chief Information Officer | William F. Hogue |
| Vice Provost and Executive Dean | Chris P. Plyler |
| Chancellor, USC Aiken | Thomas L. Hallman |
| Chancellor, USC Beaufort | Jane Upshaw |
| Chancellor, USC Spartanburg | John C. Stockwell |
| Dean, USC Lancaster | John Catalano |
| Dean, USC Salkehatchie | Ann C. Carmichael |
| Dean, USC Sumter | C. Leslie Carpenter |
| Dean, USC Union | James W. Edwards |