| President | Harris Pastides |
| Vice President for Academic Affairs and Provost | Michael D. Amiridis |
| Vice President of Business and Finance and Chief Financial Officer | Edward L. Walton |
| Secretary of the Board of Trustees/University Secretary | Amy Stone |
| Vice President for Student Affairs,
Vice Provost for Academic Support, and Dean of Students |
Dennis A. Pruitt |
| General Counsel | Walter H. Parham |
| Vice President for Research | Prakash Nagarkatti |
| Vice President for Information Technology & Chief Information Officer | William F. Hogue |
| Vice President for Development and Alumni Relations | Jancy Houck |
| Interim Vice President for Communications | Wes Hickman |
| Chancellor, USC Aiken | Sandra Jordan |
| Chancellor, USC Beaufort | Jane T. Upshaw |
| Chancellor, USC Upstate | Thomas F. Moore |
| Dean, USC Lancaster | Walter Collins |
| Dean, USC Salkehatchie | Ann C. Carmichael |
| Dean, USC Sumter | Michael E. Sonntag |
| Dean, USC Union | Alice Taylor-Colbert |