| President | Harris Pastides |
| Executive Vice President for Academic Affairs and Provost | Joan T.A. Gabel |
| Vice President for Finance and Chief Financial Officer | Leslie Brunelli |
| Secretary of the Board of Trustees/University Secretary | Amy Stone |
| Vice President for Student Affairs, Vice Provost for Academic Support and Dean of Students | Dennis A. Pruitt |
| General Counsel and Executive Director of Compliance Programs | Walter H. Parham |
| Vice President for Research | Prakash Nagarkatti |
| Vice President for Information Technology and Chief Information Officer | William F. Hogue |
| Vice President for Development and Alumni Relations | Jancy Houck |
| Director, Communications and Marketing/Chief Communications Officer | Wes Hickman |
| Chancellor, USC Aiken | Sandra Jordan |
| Chancellor, USC Beaufort | Al M. Panu |
| Chancellor, USC Upstate | Thomas F. Moore |
| Dean, USC Lancaster | Walter Collins |
| Dean, USC Salkehatchie | Ann C. Carmichael |
| Dean, USC Sumter | Michael E. Sonntag |
| Dean, USC Union | Alice Taylor-Colbert |